LIPOPROTEIN PARTICLE PROFILE PLUS
LIPOPROTEIN PARTICLE PROFILE + (LPP+) LAB TEST
WHAT IS TESTED FOR IN A LIPOPROTEIN PARTICLE PROFILE + LAB TEST?
The Lipoprotein Particle Profile Plus (LPP+™) Panel consists of the following:
1.Lipoprotein Particle Numbers
2.Biomarkers and Risk Factors, including Lipoprotein (a), High Sensitivity C-Reactive Protein, Apolipoprotein B, Insulin and Homocysteine
3.Lipid Panel including Total Cholesterol, HDL Cholesterol, LDL Cholesterol and Triglycerides
AM I REQUIRED TO FAST FOR THIS LAB TEST?
Yes. You must fast at least eight (8) hours prior to having your specimen collected.
About 50% of people who have suffered heart attacks have “normal” cholesterol numbers (NHLB I – The National Heart, Lung and Blood Institute). It is the number and density (size) of Low Density Lipoprotein cholesterol, “LDL” or “bad” cholesterol that provides the clearest picture of a person’s cardiovascular risk. The smaller LDL particles carry cholesterol throughout the body, but it is the large number and smaller density of these particles, not the cholesterol within them, that causes plaque buildup in the arteries. People who have low High Density Lipoprotein (HDL or “good” cholesterol) numbers or high triglycerides are more likely to be at a greater risk of cardiovascular disease and undetected risk factors such as very small, dense lipoproteins.
The LPP+™ test is the most advanced test available to predict heart disease risk, much more so than standard cholesterol testing. It measures the lipoprotein particles directly giving a more precise evaluation of their size. High numbers of small, dense LDL particles can ultimately cause cardiovascular disease. The National Cholesterol Education Program (NCEP) has identified new lipoprotein risk factors to help identify potential heart attack victims with these “normal” numbers. The new risk factors, Remnant Lipoprotein (RLP), Small Dense LDL, Lipoprotein (a) (Lp(a), and HDL 2b & 3, will not show up in a standard cholesterol test. The first three lipoproteins are high in 25% of the population, while the last, the “good” HDL types, large, buoyant particles that pick up excess cholesterol from the blood, is low in 25% of the population but those who haven’t had the LPP+™ test do not know whether they are at risk.
WHY DO I NEED THE LPP+ LAB TEST?
Although you may have “normal” cholesterol numbers, you aren’t getting a complete picture of your cardiovascular risk with standard cholesterol testing. The advanced LPP+™ test looks at the new risk factors identified by the NCEP and allows your physician to make changes to your treatment plan, or put one in place, to be more aggressive in preventing heart attacks and stroke.
The LPP+™ test also includes tests for Metabolic Syndrome traits, precursors for diabetes and heart disease, such as insulin and homocysteine. Early detection of these heart disease risk factors can help you prevent heart attack and stroke and provide peace of mind that you have done all your research and have the right information for the healthiest you going forward.
Lipoprotein Particle Numbers
VLDL (Very Low Density Lipoproteins): <85
Total LDL Particles: <900
Non-HDL ParticlesRLP (Remnant Lipoproteins): <1000<150
Small – Dense LDL III: <300
Small – Dense LDL IV: <100
Total HDL ParticlesLarge – Buoyant HDL 2b: >7000>1500
Biomarkers and Risk Factors
Apo B-100: 40-100
Metabolic Syndrome Traits: 0
High Sensitivity C-Reactive Protein: <3.0
Total Cholesterol: <200
LDL – Cholesterol: 40-130
HDL – Cholesterol: >40
Non – HDL – Cholesterol: <160
HIGH RESULTS INDICATE:
High results indicate a greater risk of heart disease, especially when accompanied by low levels of HDL cholesterol.
LOW RESULTS INDICATE:
Low results indicate a reduced risk of heart disease especially when accompanied by high levels of HDL cholesterol.
WHAT TYPE OF PHYSICIAN SHOULD I SEE?
If your test results are abnormal our out-of-range, you should see your primary care physician.